HPLC ≥99.0% | MS-IDENTIFIED | CAS-TRACEABLE | CoA PER BATCH

Qingdao Sigma Chemical

Analytical-grade research peptide & compound catalog · Vol. VII / 2026
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Pharma-grade research peptides, with full analytical traceability.

Qingdao Sigma Chemical supplies analytical-grade research peptides and compounds. Every catalog entry carries a CAS reference, molecular formula and weight, with HPLC purity ≥99.0% and ESI-MS identity confirmation on every production batch.

The catalog spans GLP-1 receptor agonists, growth-hormone secretagogues, cyclic peptides, and selected reference standards. Each shipment includes a Certificate of Analysis bearing the batch number, retention time, observed [M+H]⁺ mass and assay value.

Worldwide distribution: China · UK · US · Germany · Canada. Lyophilized powder, sterile-filtered, vial-sealed under inert atmosphere.

§ Catalog

Selected research peptides & compounds

Cat. No.CompoundCASMWSpecPriceOrder
TR5Tirzepatide
C225H348N48O68
2023788-19-24813.455mg*10vials$40Order →
SM2Semaglutide
C187H291N45O59
910463-68-24113.582mg*10vials$30Order →
TR30PTirzepatide 30mg Pen Kit
C225H348N48O68
2023788-19-24813.4530mg*10 pens (click-dose)$250Order →
RT5Retatrutide
C221H343N47O67
2381089-83-24731.05mg*10vials$65Order →
RT30PRetatrutide 30mg Pen Kit
C221H343N47O67
2381089-83-24731.030mg*10 pens (click-dose)$335Order →
BT5TB-500 (TB4)
C43H69N12O12P
77591-33-4889.015mg*10vials$65Order →
B10FTB-500 FRAG
C43H69N12O12P
77591-33-4889.0110mg*10vials$85Order →
BC5BPC-157
C62H98N16O22
137525-51-01419.555mg*10vials$35Order →
2ADAOD9604
C78H125N23O23S2
221231-10-31817.052mg*10vials$45Order →
BB10BPC157 5mg + TB500 5mg Blend
C62H98N16O22
137525-51-01419.5510mg*10vials$85Order →
BB20BPC157 10mg + TB500 10mg Blend
C62H98N16O22
137525-51-01419.5520mg*10vials$150Order →
BBG50GLOW GHK-CU 35mg+TB500 10mg+BPC157 5mg
C62H98N16O22
137525-51-01419.5550mg*10vials$150Order →

Pricing per vial / unit. 12 compounds in selected catalog. Bulk and OEM pricing on enquiry.

§ QC Specifications

Analytical methodology

Quality assurance & analytical methods

All catalog compounds are analysed using a documented QC pipeline derived from ICH Q2 & Q7 guidelines. The following methods apply across the catalog unless a compound-specific monograph indicates otherwise.

Identity
ESI-MS
Observed [M+H]⁺ within ±0.5 Da of theoretical
Purity
RP-HPLC, UV-DAD
Threshold ≥99.0% (peptide content)
Assay
AAA / N-content
Amino-acid analysis or nitrogen quantification
Endotoxin
< 0.5 EU/mg
LAL kinetic chromogenic per USP <85>
Form
Lyophilised powder
Sterile-filtered prior to lyophilisation
Storage
−20 °C, desiccated
Long-term stability validated to 36 months
Container
Type-I borosilicate vial
Butyl-rubber septum, aluminium crimp seal
Documentation
CoA per batch
Independent third-party verification on file
Standards aligned ICH Q2(R1) ICH Q3D ICH Q3C ICH Q7 ICH Q1A(R2) USP <71> USP <85> USP <61> USP <62> USP <788> USP <1226> EP 2.6.14 EP 2.9.20 JP 4.01 ISO 9001:2015 ISO/IEC 17025
Analytical record · Lot B-2026-0428-001

Reference standard — full analytical profile

Every batch is released against a written specification with identity (LC-MS), assay (RP-HPLC), endotoxin (LAL), water (Karl-Fischer), residual solvents (GC-headspace) and microbial limits — recorded on a per-lot Certificate of Analysis.

RP-HPLC trace · purity
Tirzepatide
Rt 12.84 min
99.74%
Rt 12.84 min · 99.74% · API peak Rt 18.7 · 0.21% impurity RP-HPLC C18 · 0.1% TFA · MeCN/H₂O · 220 nm Phenomenex Luna 250×4.6 mm · 5 μm
ESI-Q-TOF MS · identity
[M+H]⁺ confirmed
m/z 100 – 6000
±0.3 Da
[M+H]⁺ · base peak [M+2H]²⁺ [M+Na]⁺ ESI-Q-TOF · positive ion · m/z 100 – 6000 Bruker Compact · ±0.5 Da
Purity (HPLC)
99.74%
UV-DAD 220 nm · A%
Identity (MS)
[M+H]⁺ ✓
±0.3 Da of theoretical
Endotoxin
< 0.05 EU/mg
LAL kinetic · USP <85>
Water (KF)
2.3% w/w
Coulometric titration
Certificate of Analysis
Tirzepatide · Lot B-2026-0428-001
Mfg 2026-04-28
Exp 2029-04-28
CompoundTirzepatide
CAS number2023788-19-2
Molecular formulaC225H348N48O68
Molecular weight4813.45 g/mol
AppearanceWhite to off-white lyophilised cake
SolubilityFreely soluble in water (≥ 5 mg/mL); soluble in 0.1 M acetic acid
Identity (ESI-Q-TOF)[M+H]⁺ ±0.3 Da of theoretical · matches reference spectrum
Assay (RP-HPLC, A%)99.74% (Spec ≥ 98.0%)
Net peptide content88.4% w/w (AAA)
Endotoxin (LAL kinetic)< 0.05 EU/mg · USP <85> (Spec < 5.0 EU/mg)
Microbial — TAMC< 10 CFU/g · USP <61> (Spec < 100)
Microbial — TYMC< 10 CFU/g · USP <61> (Spec < 10)
Specified microorganismsAbsent · USP <62> (S. aureus / E. coli / P. aeruginosa)
Water content (KF)2.3% w/w (Spec ≤ 5.0%)
Acetate counter-ion7.8% w/w · ion chromatography
TFA residual< 1.0% · ¹⁹F-NMR
Heavy metals (total)< 10 ppm · ICH Q3D · ICP-MS
FormLyophilised, sterile-filtered (0.22 μm), N₂-purged amber glass vial
Backbone topology · structural reference
Tirzepatide · primary structure
Fmoc-SPPS · TFA cleavage · RP-HPLC purified
H₂N R₁ R₂ R₃ R₄ R₅ O O O O O OH Cα Cα Cα Cα Cα Cα Generic peptide backbone — amide bonds, side chains R₁–Rₙ — synthesised by Fmoc-SPPS, cleaved with TFA cocktail K, RP-HPLC purified
— Reference standard programme · synthesis → QC → release —

Endotoxin · microbial limits · elemental impurities

USP <85> · <61> · <62> · ICH Q3D
Bacterial endotoxins
< 0.05 EU/mg
LAL kinetic chromogenic · USP <85>
Total aerobic count
< 10 CFU/g
USP <61> · TAMC
Total yeast / mould
< 10 CFU/g
USP <61> · TYMC
Specified microorganisms
absent
USP <62> · S. aureus / E. coli / P. aeruginosa
Heavy metals (total)
< 10 ppm
ICH Q3D · ICP-MS · Pb/Cd/As/Hg
Sterility · USP <71>
no growth
14-day · FTM + SCDM · membrane filtration
Acetate content
7.8% w/w
Counter-ion · ion chromatography
TFA residual
< 1.0%
Trifluoroacetate · ¹⁹F-NMR

Residual solvents — ICH Q3C(R8)

GC headspace · FID
Class Solvent PDE / limit Result Status
Class 1Benzene2 ppmnot detected● pass
Class 1Carbon tetrachloride4 ppmnot detected● pass
Class 2Acetonitrile410 ppm38 ppm● pass
Class 2Dichloromethane600 ppm21 ppm● pass
Class 2N,N-DMF880 ppm112 ppm● pass
Class 3Ethanol5000 ppm86 ppm● pass
Class 3Ethyl acetate5000 ppm42 ppm● pass
Container · closure system
2 mL Type I amber borosilicate glass vial · 13 mm bromobutyl-rubber stopper (B2-40, FluroTec® coated) · aluminium flip-off seal · headspace purged with dry N₂. Tested per USP <1660> · <381> · <671> for moisture vapour transmission.
Particulate matter · USP <788>
Method 1 · light obscuration. ≥ 10 μm: 18 / mL (limit ≤ 6000); ≥ 25 μm: 1 / mL (limit ≤ 600). Reconstituted 1 mg/mL in water-for-injection. EP 2.9.19 cross-validated. Pass.
Bioactivity · receptor binding
In-vitro binding assay vs. cognate reference standard. EC₅₀ relative potency 96 – 104% (n=3). cAMP accumulation HEK-293 stable line · LANCE® TR-FRET · 4-parameter logistic fit. Within ±10% spec.

Real-time stability data — 36 months @ −20 °C

ICH Q1A(R2) · long-term + accelerated arms
t (mo) Storage Assay (HPLC) Δ vs t₀ Endotoxin Water (KF) Status
0−20 °C, dry99.74%reference< 0.05 EU/mg2.3%● t₀
3−20 °C, dry99.73%−0.01%< 0.05 EU/mg2.3%● within spec
6−20 °C, dry99.71%−0.03%< 0.05 EU/mg2.4%● within spec
12−20 °C, dry99.65%−0.09%< 0.05 EU/mg2.5%● within spec
24−20 °C, dry99.52%−0.22%< 0.05 EU/mg2.6%● within spec
36−20 °C, dry99.41%−0.33%< 0.07 EU/mg2.7%● within spec
Test points t = 0, 3, 6, 9, 12, 18, 24, 30, 36 mo. Acceptance criterion: assay ≥ 95.0% of t₀, endotoxin < 5.0 EU/mg, water ≤ 5.0% w/w. Accelerated arm 25 °C / 60% RH passed without specification deviation through 6 months.

Analytical method strings

validated per ICH Q2(R1) · linearity / accuracy / precision / specificity / LOD-LOQ
RP-HPLC · purity / assay
Phenomenex Luna C18(2), 250 × 4.6 mm, 5 μm. Mobile A: 0.1% TFA in H₂O · B: 0.1% TFA in MeCN. Gradient 20 → 80% B over 30 min, hold 5 min. Flow 1.0 mL/min. Column 35 °C. UV-DAD 220 nm. Injection 20 μL · 1 mg/mL.
ESI-Q-TOF MS · identity
Bruker Compact Q-TOF · positive ion. m/z 100 – 6000. Capillary 4500 V. Nebuliser 1.6 bar. Dry gas 8.0 L/min @ 200 °C. Mass accuracy ±0.5 Da of theoretical [M+H]⁺ / [M+2H]²⁺ / [M+3H]³⁺.
LAL kinetic chromogenic · endotoxin
Charles River Endosafe nexgen-PTS · USP <85> / EP 2.6.14 / JP 4.01. Sensitivity 0.005 – 50 EU/mL. MVD calculated from CSE. Acceptance: spike recovery 50 – 200%; r ≥ 0.980 over standard curve.
Karl-Fischer · water content
Metrohm 870 KF Titrino plus · coulometric. Anode HYDRANAL Coulomat AG. Sample 50 – 100 mg, headspace-free. Acceptance ≤ 5.0% w/w. Reported to 0.1% precision. Cross-checked vs. TGA.
ICP-MS · elemental impurities
Agilent 7900 ICP-MS · ICH Q3D Option 1. Sample digestion: closed-vessel microwave (HNO₃ + H₂O₂). Target panel: Pb, Cd, As, Hg + Class 2A/2B. RSD ≤ 5%. Recovery 70 – 150% of spiked control.
AAA · amino-acid analysis
Hitachi L-8900 · post-column ninhydrin. Hydrolysis 6 N HCl · 110 °C · 24 h, vacuum-sealed, phenol added. Reports residue ratios + net peptide content (anchor for assay value). Cross-validated vs. nitrogen elemental analysis.
Quality system
ISO 9001:2015 certified
Certificate CN-11/Q-2417 · TÜV Rheinland
Test laboratory
ISO/IEC 17025 accredited
Scope: chemical & biological testing
Manufacturing
ICH Q7-aligned API
Process validation 3 consecutive batches
Compendial cross-ref
USP-NF · EP · JP · ChP
Specifications mapped to monograph chapters
Place an order against this catalog
Bulk pricing, milligram–gram scale, full CoA on every shipment
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§ Correspondence & ordering

Place an order on the website

All orders are placed online. Browse the full catalog, select compounds and quantities, apply discount code PAYDAY for 20% off your first order. Worldwide shipping with full Certificate of Analysis on each shipment.

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Technical correspondence
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+1 (341) 345-8639
Email
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